Humoral Theory of Transplantation

The Humoral Theory of Transplantation

Cardiohepatic Interactions - from Humoral Theory to Organ Transplantation

Cardiohepatic Interactions – from Humoral Theory to Organ Transplantation Odilson Marcos Silvestre1, Fernando Bacal1, Rafael Oliveira Ximenes2, Flair José Carrilho2, Luiz Augusto Carneiro D’Albuquerque2, Alberto Queiroz Farias2 Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo1; Hospital das Clínicas da Faculdade de Medicina da Universidade de S...

From Humoral Theory to Performant Risk Stratification in Kidney Transplantation

The purpose of the present review is to describe how we improve the model for risk stratification of transplant outcomes in kidney transplantation by incorporating the novel insights of donor-specific anti-HLA antibody (DSA) characteristics. The detection of anti-HLA DSA is widely used for the assessment of pre- and posttransplant risks of rejection and allograft loss; however, not all anti-HLA...

The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies

Central to the humoral theory of transplantation is production of antibodies by the recipient against mismatched HLA antigens in the donor organ. Not all mismatches result in antibody production, however, and not all antibodies are pathogenic. Serologic HLA matching has been the standard for solid organ allocation algorithms in current use. Antibodies do not recognize whole HLA molecules but ra...

Cellular and Humoral Response to Transplantation Antigens

After transfer into heavily-irradiated allogeneic mice, spleen cells were found to produce two types of effector cells directed against the recipient alloantigens, namely alloantibody plaque-forming cells (PFC) and cytotoxic lymphocytes (CL). Both types of effector cells were detectable in vitro by virtue of their lytic effect on target cells carrying the recipient alloantigens. Alloantibody PF...